The paper deals with the theory of entrepreneurship and factors that determine the conditions of the regional policy in the field of entrepreneurship. Attention is paid to the formation of the business climate, which should be in close relationship with the fundamentals of business infrastructure. As business activities related to venture business, which carries a high risk of predetermining conditions for doing the business. Recommendations of doing successful business in the region, taking into account the peculiarities of a particular area of ​​the economy.